The Observation of Biological Characteristics of Hybrid Cell in Mice

Cell fusion between mouse myeloma NS-1 and mouse spleen cells was induced by polyethylene glycol (PEG).Hyrid cells were successfully obtained by HAT medium.The hybridcell population were examined 30,50,70 and 90 days after fusion,The G-,C- banding and the frequencies of chromosomal aberrations in parental and hybrid cells were then compared.