A Thrombin Inhibitor from Ixodid Tick,Ixodide sinesis

WANG Li-ju; GAO Guo-fu; BAI Shi-ping; LIU Zhi-gang; LIANG Jian-guo et al.

WANG Li-ju, GAO Guo-fu, BAI Shi-ping, LIU Zhi-gang, LIANG Jian-guo et al.. 2005. A Thrombin Inhibitor from Ixodid Tick,Ixodide sinesis. Zoological Research, 26(3): 328-331.

Citation:

WANG Li-ju, GAO Guo-fu, BAI Shi-ping, LIU Zhi-gang, LIANG Jian-guo et al.. 2005. A Thrombin Inhibitor from Ixodid Tick,Ixodide sinesis. Zoological Research, 26(3): 328-331.

Citation:

WANG Li-ju, GAO Guo-fu, BAI Shi-ping, LIU Zhi-gang, LIANG Jian-guo et al.. 2005. A Thrombin Inhibitor from Ixodid Tick,Ixodide sinesis. Zoological Research, 26(3): 328-331.

A Thrombin Inhibitor from Ixodid Tick,Ixodide sinesis

Graphical Abstract

Abstract

Abstract

A novel thrombin inhibitor was identified and purified from salivary glands of ixodid tick,Ixodide sinesis by gel filtration and RP-HPLC. The molecular weight was 6.356 kDa determined by MALDI-TOF mass spectra. It was different from any known serine protease inhibitors identified from ixodid ticks. This inhibitor inhibited thrombin with strong potency,and exhibited no obvious effects on factor Xa and trypsin. The thrombin inhibitor may be used as a candidate to develop vaccine to control ticks.